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FOR 2886 PANDORA

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(Project B3)

 

2019-2022 (1st funding period): Sodium as factor controlling the threshold of autoimmune arthritis

Sodium concentration in the extracellular milieu reportedly affects key aspects of both the innate and the adaptive immune response. However, a potential role of sodium and tissue tonicity during induction of autoimmunity and inflammation in experimental arthritis and human rheumatoid arthritis (RA) is still elusive.

picture salt

We have shown that feeding high salt diet increases skin tonicity in mice and simultaneously fosters both pathogen-triggered inflammation as well as sterile inflammatory processes such as zymosan-induced arthritis. Although underlying molecular mechanisms are still incompletely understood, p38-dependent activation of NFAT5/TonEBP/OREBP and altered transcription of osmo-protective genes are likely to be cardinally involved. The aim of this project is to analyze the role of tissue tonicity in the induction and onset of the inflammatory response in arthritis, where we will mechanistically focus on its impact on neutrophils and neutrophil extracellular trap formation and aggregation.

 

Principal Investigators

Jens Titze

Prof. Dr. med. Jens Titze

Professor für Elektrolyt- und Kreislaufforschung

Department of Medicine 4
Chair of Medicine IV

  • Phone number: 0913185-39002 -36354
  • Email: jens.titze@uk-erlangen.de
Martin Herrmann

Apl. Prof. Dr. rer. nat. Dr. med. habil. Martin Herrmann

Department of Medicine 3
Chair of Medicine III (Prof. Dr. Schett)

  • Phone number: +49 9131 85-36990
  • Email: martin.herrmann@uk-erlangen.de

Doctoral researchers

Leticija Oreski

Leticija Zlatar, M. Sc.

Department of Medicine 3
Chair of Medicine III (Prof. Dr. Schett)

  • Phone number: +49 9131 85-24787
  • Email: leticija.zlatar@uk-erlangen.de

Post Docs

Aparna Mahajan

Aparna Mahajan

Department of Medicine 3
Chair of Medicine III (Prof. Dr. Schett)

  • Phone number: +49 9131 85-24787
  • Email: aparna.mahajan@uk-erlangen.de
Jasmin Knopf

Dr. rer. nat. Jasmin Knopf

Department of Medicine 3
Chair of Medicine III (Prof. Dr. Schett)

  • Phone number: +49 9131 85-24787
  • Email: jasmin.knopf@uk-erlangen.de
Universitätsklinikum Erlangen
Medizinische Klinik 3

Universitätsstr. 25a
91054 Erlangen
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