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Project C1

 

Combined B cell/T cell therapy as novel approach for the re-induction of humoral immune-tolerance

Despite advances in the treatment of rheumatoid arthritis (RA) and the development of effective anti-inflammatory therapies, this chronic inflammatory autoimmune disease remains incurable. In the proposed clinical trial, we plan to sequentially use combined B-cell and T-cell therapy. ACPA-positive RA patients receive therapy with rituximab for B-cell depletion and subsequent blockade of T-cell co-stimulation by administration of abatacept. The primary endpoint of this study is the proportion of anti-cyclic citrullinated (CCP) 2 antibody seroconversions in anti-CCP2 positive RA patients at a given time, while secondary outcomes will be changes in autoantibody glycosylation as well as B cell response as well as the effects on clinical disease activity.

Prof. Dr. med. Gerhard Krönke

Professorship for Translational Immunology

Department of Medicine 3
Chair of Medicine III (Prof. Dr. Schett)